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Research

Chemical Pathology

 

Overview

Chemical pathology is a branch of pathology which involves the analysis and interpretation of biochemical tests for screening, diagnosis, management and prevention of diseases. This field discusses the biochemical changes in a wide range of substances in blood and body fluids such as glucose, enzymes, hormones, minerals, ions, RNA, DNA and others in order to understand the etiology, pathophysiology and progression of a disease. It also encompasses fundamental biochemistry research of the structure, composition and chemical reactions of substances in living systems giving emphasis on the development, evaluation and validation of new technologies. Research in this area may include but not limited to pharmacology, physiology, microbiology, molecular biology, immunochemistry, neurochemistry, bioinorganic, bioorganic and biophysical chemistry. This program awards students with a Master or Doctor of Philosophy in Chemical Pathology on completion of the necessary credit hours as stipulated by the Graduate School as well as on successfully passing the thesis of a research.

Research Area

  • Cardiovascular
  • Diabetes Melitus
  • Adrenal Hyperplasia

Group Members with Area of Specialization

  • Assoc. Prof. Dr. Zalinah Ahmad (Metabolic Syndrome, Molecular Biology)
  • Dr. Ho Kok Lian (Proteomics and Protein Crystalization, Biochemistry)
  • Dr. Intan Nureslyna Samsudin (Endocrinology, Chemical Pathology)
  • Dr. Subashini a/p Chellappah Thambiah (Lipid and Metabolic Bone Disorders, Chemical Pathology)

 

Immunology

 

Overview

Members of the Immunology unit are involved in researches to advance understanding and knowledge of the role of the immune system in health and disease. In cancer, neurodegenerative disease and allergy where inflammation has been identified as a major factor in pathogenesis, if not etiology, much fundamental work has been carried out and there is continued effort to put these into publication. Members are also interested in discovering preventive and therapeutic alternatives for the treatment of these diseases, testing a wide range of methodologies from natural extracts (of local herbs, microbial products, fruits, and vitamins) to stem cell therapies and immunotherapy. Another area of interest is in identifying biomarkers in various cancers.

 

Research Area

  • Mechanisms of drug resistance and relapse in acute leukaemias
  • Effects of fruits and herbs on the healthy immune system
  • Immune dysregulation and symptom severity in allergic rhinitis
  • Immunomodulatory activity of human mesenchymal stem cells
  • Anti-tumourigenic effect of human mesenchymal stem cells
  • Effect of herbal treatment in diabetes induced immune dis-regulation
  • Isolation and characterisation of human mesenchymal stem cells from various post natal tissues
  • Tumour immunology, viral and molecular immunology, and cancer signal transduction pathways
  • Research in microglia

Group Members with Area of Specialization

  • Professor Dr Seow Heng Fong (Molecular Immunology)
  • Assoc Prof Dr Maha Abdullah (Immunology)
  • Assoc Prof Dr Sharmili Vidyadaran (Neuroscience)
  • Assoc Prof Dr Rajesh Ramasamy (Stem Cells and Immunity)

 

Histopathology

 

Overview

Members of Histopathology Unit are actively involved in various types of research. Our aims are to enhance the understanding of pathogenesis of diseases. i) to discover novel prognostic and diagnostic biomarkers in diseases. ii) to make recommendation for the prognostic algorithm, diagnosis and novel therapeutic targets for diseases based on the research findings.

Research Area

  • Cancer: Urogenital system, digestive system, head and neck
  • Cardiovascular: Coronary heart disease, atherosclerosis

Group Members with Area of Specialization

  • Dr Norhafizah Mohtarrudin (Cancer and Cardiovascular research)

 

Haematology

 

Overview

Members of the Haematology Unit are involved in researches involving the advancement of knowledge of the haematology field primarily in thalassaemia and platelet and haemostasis research. In thalassaemia research, the focus of the research group includes determination of frequencies of different thalassaemia genes, their molecular genetics nature including gene modifiers that affect clinical manifestation, design simple cost-effective and practical protocols/algorithms for screening and definitive laboratory diagnosis of thalassaemia, determining the efficacy of cord blood haemopoietic stem cell transplantation and studying the effects of microRNAs of Hb subtypes and erythropoiesis in thalassaemia. Platelet and haemostasis area has many potential research questions which are fundamental in understanding mechanism of various diseases, differences in therapeutic response and discovering natural products with potential medicinal properties. The work in platelet & haemostasis has potential s to be translated into personalized medicine in future based on the progress in the genomic and proteomic era in current scientific era.

Research Area

  • Determine frequencies of different thalassaemia genes, their molecular genetics nature including gene modifiers that affect clinical manifestation
  • Design simple cost-effective and practical protocols/algorithms for screening and definitive laboratory diagnosis of thalassaemia.
  • Design cost effective diagnostic tools for thalassaemia and Hb Variants in healthcare system.
  • Determine efficacy of cord blood haemopoietic stem cell transplantation.
  • Effects of microRNAs of Hb subtypes and erythropoiesis in thalassaemia.
  • Determination of antiplatelet and anticoagulant activities of various medicinal plants and natural products.
  • Molecular determination of inherited bleeding disorders involving platelet receptor dysfunctions.
  • Spectrum of bleeding disorders amongst women with menorrhagia.
  • Platelet reactivity in patients with post PCI stents thrombosis
  • Platelet reactivity in patients with neurological disorders.
  • Platelet productivity in dengue.

Group Members with Area of Specialization

  • Dr Eusni Rahayu Mohd. Tohit (Platelet and Haemostasis )
  • Dr Sabariah Md Noor (Blood disorders and Anticoagulation)
  • Dr Faridah Idris (Transfusion Medicine)
  • Dr Lai Mei I (Molecular Haematology)

 

 

Updated:: 17/04/2017 [norazmie]

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