Pathology
HEAD OF PATHOLOGY DEPARTMENT
Dr. Norhafizah Mohtarrudin
BACKGROUND
The Department of Pathology was originally set up as the Department of Clinical Laboratory Sciences. Established on 1st May 1999, it was initially composed of 7 units including Histopathology, Hematology, Chemical Pathology, Immunology, Microbiology, Parasitology and Radiology. Following restructuring into clinical and pre-clinical units, the Radiology unit was then placed under Department of Medicine. On 1st June 2006, the Department of Pathology was formed and it now consists of Histopathology, Hematology, Chemical Pathology and Immunology units.
Previous Head of Department
- Associate Prof. Dr Hairuszah Ithnin ( 1st July 2001 - 2nd August 2010)
- Associate Prof. Dr Sabariah Abdul Rahman ( June 1999 - 30th June 2001)
Organization Structure
- Head of Department : Dr. Norhafizah Mohtarrudin
- Head Unit :
- Chemical Pathology Unit: Dr. Zalinah Ahmad
- Immunology Unit: Assoc. Prof. Dr. Maha Abdullah
- Histopathology Unit : Assoc. Prof. Dr. Hairuszah Ithnin
- Haematology Unit : Dr. Faridah Idris
- Science Officer : Mrs. Safarina Mohd. Ismuddin
Contact
- Telephone Number : 03-89472392
- Fax Number : 03-89412787
Academic
UNDERGRADUATE
POSTGRADUATE
Pathology is the study (logos) of disease (pathos). It addresses cause/etiology, mechanisms of development (pathogenesis), structural alterations of cells (morphologic changes), and the consequences of changes (clinical manifestations). The Masters of Pathology programme is based on apprenticeship. This programme requires candidates to fulfill both coursework as outlined by the department, and clinical duties as assigned. The general objective in Part I is to attain basic knowledge and practical competence in General Pathology. Part II is to acquire consultant level skills in evaluation, interpretation and advice on diagnostic laboratory procedures, acquire skills on total quality management of diagnostic services and also to acquire competence to complete a simple research project.
- Masters of Science (Immunobiology)
- Masters of Science (Hematology)
- Masters of Science (Chemical Pathology)
Ph.D
Research
- Cancer: Nasopharyngeal, breast, colorectal, ovary, endometrium, gastric, prostate, renal, leukemia
- Hematology: Red blood cells disorders, Thalassemia, anti-coagulation/anti-platelet
- Cardiovascular: Coronary heart disease, atherosclerosis
- Diabetes Melitus
- Neuroinflammation
- Mesenchymal stem cells
- Immunology: Allergy
Chemical Pathology
Overview
Chemical pathology is a branch of pathology which involves the analysis and interpretation of biochemical tests for screening, diagnosis, management and prevention of diseases. This field discusses the biochemical changes in a wide range of substances in blood and body fluids such as glucose, enzymes, hormones, minerals, ions, RNA, DNA and others in order to understand the etiology, pathophysiology and progression of a disease. It also encompasses fundamental biochemistry research of the structure, composition and chemical reactions of substances in living systems giving emphasis on the development, evaluation and validation of new technologies. Research in this area may include but not limited to pharmacology, physiology, microbiology, molecular biology, immunochemistry, neurochemistry, bioinorganic, bioorganic and biophysical chemistry. This program awards students with a Master or Doctor of Philosophy in Chemical Pathology on completion of the necessary credit hours as stipulated by the Graduate School as well as on successfully passing the thesis of a research.
Research Area
- Cardiovascular
- Diabetes Melitus
- Adrenal Hyperplasia
Group Members with Area of Specialization
- Dr. Ho Kok Lian (Proteomics and Protein Crystalization, Biochemistry)
- Dr. Intan Nureslyna Samsudin (Endocrinology, Chemical Pathology)
- Dr. Subashini a/p Chellappah Thambiah (Lipid and Metabolic Bone Disorders, Chemical Pathology)
- Dr. Zalinah Ahmad (Metabolic Syndrome, Molecular Biology)
Immunology
Overview
Members of the Immunology unit are involved in researches to advance understanding and knowledge of the role of the immune system in health and disease. In cancer, neurodegenerative disease and allergy where inflammation has been identified as a major factor in pathogenesis, if not etiology, much fundamental work has been carried out and there is continued effort to put these into publication. Members are also interested in discovering preventive and therapeutic alternatives for the treatment of these diseases, testing a wide range of methodologies from natural extracts (of local herbs, microbial products, fruits, and vitamins) to stem cell therapies and immunotherapy. Another area of interest is in identifying biomarkers in various cancers.
Research Area
- Mechanisms of drug resistance and relapse in acute leukaemias
- Effects of fruits and herbs on the healthy immune system
- Immune dysregulation and symptom severity in allergic rhinitis
- Immunomodulatory activity of human mesenchymal stem cells
- Anti-tumourigenic effect of human mesenchymal stem cells
- Effect of herbal treatment in diabetes induced immune dis-regulation
- Isolation and characterisation of human mesenchymal stem cells from various post natal tissues
- Tumour immunology, viral and molecular immunology, and cancer signal transduction pathways
- Research in microglia
Group Members with Area of Specialization
- Professor Dr Seow Heng Fong (Molecular Immunology)
- Assoc Prof Dr Maha Abdullah (Immunology)
- Dr Sharmili Vidyadaran (Neuroscience)
- Dr Rajesh Ramasamy (Stem Cells and Immunity)
Histopathology
Overview
Members of Histopathology Unit are actively involved in various types of research. Our aims are • to enhance the understanding of pathogenesis of diseases. • to discover novel prognostic and diagnostic biomarkers in diseases. • to make recommendation for the prognostic algorithm, diagnosis and novel therapeutic targets for diseases based on the research findings.
Research Area
- Cancer: Urogenital system, digestive system, head and neck
- Cardiovascular: Coronary heart disease, atherosclerosis
Group Members with Area of Specialization
- Dr Norhafizah Mohtarrudin (Cancer and Cardiovascular research)
Haematology
Overview
Members of the Haematology Unit are involved in researches involving the advancement of knowledge of the haematology field primarily in thalassaemia and platelet and haemostasis research. In thalassaemia research, the focus of the research group includes determination of frequencies of different thalassaemia genes, their molecular genetics nature including gene modifiers that affect clinical manifestation, design simple cost-effective and practical protocols/algorithms for screening and definitive laboratory diagnosis of thalassaemia, determining the efficacy of cord blood haemopoietic stem cell transplantation and studying the effects of microRNAs of Hb subtypes and erythropoiesis in thalassaemia. Platelet and haemostasis area has many potential research questions which are fundamental in understanding mechanism of various diseases, differences in therapeutic response and discovering natural products with potential medicinal properties. The work in platelet & haemostasis has potential s to be translated into personalized medicine in future based on the progress in the genomic and proteomic era in current scientific era.
Research Area
- Determine frequencies of different thalassaemia genes, their molecular genetics nature including gene modifiers that affect clinical manifestation
- Design simple cost-effective and practical protocols/algorithms for screening and definitive laboratory diagnosis of thalassaemia.
- Design cost effective diagnostic tools for thalassaemia and Hb Variants in healthcare system.
- Determine efficacy of cord blood haemopoietic stem cell transplantation.
- Effects of microRNAs of Hb subtypes and erythropoiesis in thalassaemia.
- Determination of antiplatelet and anticoagulant activities of various medicinal plants and natural products.
- Molecular determination of inherited bleeding disorders involving platelet receptor dysfunctions.
- Spectrum of bleeding disorders amongst women with menorrhagia.
- Platelet reactivity in patients with post PCI stents thrombosis
- Platelet reactivity in patients with neurological disorders.
- Platelet productivity in dengue.
Group Members with Area of Specialization
- Prof Dr. Elizabeth George (Head of Thalassaemia Niche Area)
- Dr Eusni Rahayu Mohd. Tohit (Platelet and Haemostasis )
- Dr Sabariah Md Noor (Blood disorders and Anticoagulation)
- Dr Faridah Idris (Transfusion Medicine) Dr Lai Mei I (Molecular Haematology)
Professional Services
- Histopathology and Cytology Diagnostic
Location : Pathology Department and Kuala Lumpur General Hospital
Time : 8.00 a.m – 5.00 p.m.
Pathologists: Assoc. Prof. Dr. Hairuszah Ithnin, Phone : 8947 2385 Email:
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Assoc. Prof. Dr. Sabariah Abdul Rahman, Phone : 8947 2120 Email :
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Dr Lee Bang Rom, Phone : 8947 2388 Email :
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- Histopathology Diagnostic
Location : Pathology Department and Serdang Hospital
Time : 8.00 a.m. – 5.00 p.m.
Pathologists: Assoc. Prof. Dr. Shiran Mohd Sidik, Phone : 8947 2382 Email:
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Dr. Norhafizah Mohtarrudin, Phone : 8947 2383 Email :
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Dr Razana Mohd Ali, Phone : 8947 2384 Email :
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Dr Herni Talib, Phone : 8947 2658 Email :
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Dr Huzlinda Husin, Phone: 8947 2781 Email :
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- Haematology Diagnostic
Location : Pathology Department, Serdang Hospital and Kuala Lumpur General Hospital
Time : 8.00 pg – 5.00 ptg
Pathologists: Dr. Eusni Rahayu Mohd Tohit, Phone : 8947 2379 Email :
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Dr. Zainina Seman, Phone : 8947 2380 Email :
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Dr. Faridah Idris, Phone : 8947 2378 Email :
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Dr. Sabariah Md Noor, Phone : 8947 2761 Email :
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- Thalassaemia Research
Location : Haematology Lab
Time : Monday - Friday (8.00 a.m. -12.00 noon) ; (2.30 p.m. – 5.00 p.m.)
Pathologists: Prof. Dr. Elizabeth George (Head of Research), Phone : 8947 2381 Email :
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Dr. Lai Mei I, Phone : 03 8947 2494 Emel :
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- Chemical Pathology Diagnostic
Location : Pathology Department and Kuala Lumpur General Hospital
Time : 8.00 am – 5.00 pm
Pathologists: Dr. Subashini C. Thambiah, Phone : 8947 2779 Email :
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Dr. Intan Nureslyna Samsudin, Phone : 8947 2374 Email :
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Facilities
TEACHING/RESEARCH/DIAGNOSTIC SERVICES
- Histopathology Lab - Block B, Level 2, Lab Building
Assoc. Prof. Dr. Hairuszah Ithnin (Supervisor)
Juita Chupri (Senior Medical Laboratory Technician)
Zamzarina Ahmad Bajari (Medical Laboratory Technician)
Normah Ibrahim (Assistant Scientific Officer)
Mior Ahmad Alang Mior (General Worker)
- Immunology Lab - Block D, Level 2, Lab Building
Dr. Maha Abdullah (Supervisor)
Marsitah Abd Jalil (Medical Laboratory Technician)
Siti Aishah Daud (Assistant Scientific Officer)
Siti Hajar Ezura Muhammad (Laboratory Assistant)
Anthonysamy a/l Arokiasamy (General Worker)
- Hematology Lab - Block B, Level 2, Lab Building
Dr Faridah Idris (Supervisor)
Amrina Mohd Amin (Medical Laboratory Technician)
Nor Saidatul Badariah (Medical Laboratory Technician)
Ahmad Fahmi Abdul Halim (Assistant Scientific Officer)
- Chemical Pathology Lab - Block A, Level 2, Lab Building
Dr Zalinah Ahmad (Supervisor)
Safarina Mohd Ismuddin (Scientific Officer)
Rossalyna Rokmat (Medical Laboratory Technician)
Norazmie Mohd Ramly (Medical Laboratory Technician)
RESEARCH
- Immunology Molecular Lab - Block A, Level 2, Lab Building
Dr. Maha Abdullah (Supervisor)
Marsitah Abd Jalil (Medical Laboratory Technician)
Siti Aishah Daud (Assistant Scientific Officer)
Siti Hajar Ezura Muhammad (Laboratory Assistant)
Anthonysamy a/l Arokiasamy (General Worker)
TEACHING
- Pre-clinical Skill Laboratory II (Pathology museum) - Level 1, Administrative Building
Dr Norhafizah Mohtarrudin, Head of Pathology Department (Supervisor)
LABORATORY SERVICES (FOR RESEARCH ONLY)
Academic Staff
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.:: Professor (Medicine) ::.
.:: Professor ::.
.:: Associate Professor ::.
.:: Senior Medical Lecturer ::.
.:: Medical Lecturer ::.
.:: Medical Lecturer (Trainee) ::.
.:: Senior Lecturer ::.
.:: Tutor ::.
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Support Staff
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.:: Pengurusan Dan Profesional ::.
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